Tetrahydrofuran → HCID 74830393, compound

Participants

Role	Name	HCID	Charge
Reactant	Tetrahydrofuran	HCID 8028	—
Reactant	1-Hydroxybenzotriazole	HCID 75771	—
Reactant	Diisopropylethylamine	HCID 81531	—
Reactant	1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride	HCID 2723939	—
Reactant	4,4-Difluoropiperidine hydrochloride	HCID 2758351	—
Reactant	HCID 77502936	HCID 77502936	—
Product	HCID 74830393	HCID 74830393	—

Reaction Steps

In a manner similar to the method described in Example 27, racemic (2′S,3S,4′R)-6-chloro-4′-[5-chloro-2-(2-hydroxycarbonyl-2-methyl-ethoxy)-phenyl]-2′-(5-fluoro-2-methyl-phenyl)spiro[3H-indole-3,3′-piperidine]-2,6′(1H)-dione (150 mg, 0.263 mmol) was reacted with 4,4-difluoropiperidine hydrochloride (83 mg, 0.526 mmol), EDC.HCl (100 mg, 0.526 mmol), HOBt (71 mg, 0.526 mmol) and DIPEA (204 mg, 1.579 mmol) in anhydrous THF (3 mL) to give title compound as a white solid (40 mg).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07776875B2
Source dataset	uspto-grants-2010_08
ORD ID	ord-0fd9ac05404745f29c7ec9a3f06f63f0
Source note	uspto-grants-2010_08