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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 50449Generated: October 26, 2026

2-ETHYL-5,7-DIMETHYL-3-(4-{2-[({[(4-METHYLPHENYL)SULFONYL]AMINO}CARBONYL)AMINO]ETHYL}PHENYL)-3H-IMIDAZO[4,5-b]PYRIDINE → 3-(2-Chloro-4-{2-[({[(4-methylphenyl)sulfonyl]amino}carbonyl)amino]ethyl}phenyl)-2-ethyl-5,7-dimethyl-3H-imidazo[4,5-B]pyridine

https://huagongshe.com/reaction/50449

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-ETHYL-5,7-DIMETHYL-3-(4-{2-[({[(4-METHYLPHENYL)SULFONYL]AMINO}CARBONYL)AMINO]ETHYL}PHENYL)-3H-IMIDAZO[4,5-b]PYRIDINEHCID 9935367—
Reactant1-(4-Amino-2-chlorophenyl)ethanolHCID 18543601—
Product3-(2-Chloro-4-{2-[({[(4-methylphenyl)sulfonyl]amino}carbonyl)amino]ethyl}phenyl)-2-ethyl-5,7-dimethyl-3H-imidazo[4,5-B]pyridineHCID 21876090—

Reaction Steps

The title compound was prepared according to the procedure described in step 3 of Example 1 from 4,6-Dimethyl-3-nitro-2-pyridine (0.66 g, 3.8 mmol, step 2 of Example 1) and 4-amino-2-chloro-phenylethanol (0.72 g, 3.8 mmol, Eur. J. Med. Chem., 1996, 31, 133.).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06710054B2
Source datasetuspto-grants-2004_03
ORD IDord-61eb749d92064cc787ea68ee857a02e4
Source noteuspto-grants-2004_03