Water → HCID 77502807, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of racemic (2′R,3R,4′S)-6-chloro-4′-[5-chloro-2-(2-ethoxycarbonyl-2-methyl-ethoxy)-phenyl]-2′-(2,5-difluoro phenyl)spiro[3H-indole-3,3′-piperidine]-2,6′(1H)-dione (400 mg), NaOH (111 mg), H2O (5 mL) and THF (10 mL) was heated at 80° C. for 1 h. Then THF was removed by vacuum. The water solution was acidified by concentrated hydrochloric acid to “pH” 1. The white precipitate was collected by filtration to give title compound as a white solid (300 mg).

Provenance & Evidence