Dimethylformamide → HCID 74928828, compound

Participants

Reaction Steps

A mixture of racemic (2′S,3S,4′R)-6-chloro-4′-[5-chloro-2-(2-hydroxycarbonyl-2-methyl-ethoxy)-phenyl]-2′-(2,5-difluoro phenyl)spiro[3H-indole-3,3′-piperidine]-2,6′(1H)-dione (100 mg, 0.174 mmol), dimethylamine hydrochloride (28 mg, 0.348 mmol), EDC.HCl (66 mg, 0.348 mmol), HOBt (47 mg, 0.348 mmol) and DIPEA (135 mg, 1.044 mmol) in anhydrous DMF (3 mL) was stirred at room temperature overnight. Then the mixture was filtered and the filtrate was concentrated. The residue was purified by Prep-HPLC to give the title compound as a white solid (50 mg).

Provenance & Evidence