Isoquinoline-5-sulfonamide → 2-{4-[6-Chloro-2-ethyl-5-(trifluoromethyl)-1H-benzimidazol-1-YL]phenyl}ethyl-5-isoquinolinylsulfonylcarbamate

HRID 50451Notes

Reaction equation

HRID 50451 reaction equation
[C:1](=O)([O:27]C1C=CC=CC=1)[O:2][CH2:3][CH2:4][C:5]1[CH:10]=[CH:9][C:8]([N:11]2[C:15]3[CH:16]=[C:17]([Cl:24])[C:18]([C:20]([F:23])([F:22])[F:21])=[CH:19][C:14]=3[N:13]=[C:12]2[CH2:25][CH3:26])=[CH:7][CH:6]=1.[CH:35]1[C:44]2[C:39](=[C:40]([S:45]([NH2:48])(=[O:47])=[O:46])[CH:41]=[CH:42][CH:43]=2)[CH:38]=[CH:37][N:36]=1>>[Cl:24][C:17]1[C:18]([C:20]([F:23])([F:22])[F:21])=[CH:19][C:14]2[N:13]=[C:12]([CH2:25][CH3:26])[N:11]([C:8]3[CH:7]=[CH:6][C:5]([CH2:4][CH2:3][O:2][C:1](=[O:27])[NH:48][S:45]([C:40]4[CH:41]=[CH:42][CH:43]=[C:44]5[C:39]=4[CH:38]=[CH:37][N:36]=[CH:35]5)(=[O:47])=[O:46])=[CH:10][CH:9]=3)[C:15]=2[CH:16]=1

Participants

3

Reactant 2

HCID 9837177Isoquinoline-5-sulfonamideHCID 218764092-{4-[6-chloro-2-ethyl-5-(trifluoromethyl)-1H-benzimidazol-1-yl]phenyl}ethyl phenyl carbonate

Product 1

HCID 218760992-{4-[6-Chloro-2-ethyl-5-(trifluoromethyl)-1H-benzimidazol-1-YL]phenyl}ethyl-5-isoquinolinylsulfonylcarbamate

Procedure

The title compound was prepared according to the procedure described in step 2 of Example 243 from 2-{4-[6-chloro-2-ethyl-5-(trifluoromethyl)-1H-benzimidazol-1-yl]phenyl}ethyl phenyl carbonate and 5-isoquinolinylsulfonamide.

Sources & evidence

ORD record
ord-f669b3dc21674d2aad17cb88bbf454e4
Source dataset
uspto-grants-2004_03
Patent number
US06710054B2

Reaction notes

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