Water → HCID 131728296, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of racemic (2′R,3S,4′R)-6-chloro-4′-[5-chloro-2-(1-ethoxycarbonyl-1-methyl-ethoxy)-phenyl]-2′-(2-chloro-5-fluoro-phenyl)spiro[3H-indole-3,3′-piperidine]-2,6′(1H)-dione (150 mg, 0.24 mmol), NaOH (70 mg, 1.75 mmol), H2O (2 mL) and THF (6 mL) was heated at 70° C. for 1 h. After cooled to room temperature, the solution was concentrated and the residue was acidified to “pH” 2-3 by addition of concentrated aqueous HCl. The white solid was collected by filtration to give the title compound which was used for next step reaction without further purification.

Provenance & Evidence