Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Pyrrolidine | HCID 31268 | — |
| Reactant | 6-Chloro-1,3-dihydroindol-2-one | HCID 736344 | — |
| Reactant | HCID 57565879 | HCID 57565879 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | HCID 86632067 | HCID 86632067 | 78.1% |
Reaction Steps
To the mixture of 6-chlorooxindole (5.3 g, 31.7 mmol) and 2-(4-fluoro-2-formyl-phenoxy)-2-methyl-propionic acid ethyl ester (8 g, 31.7 mmol) in methanol (30 mL) was added pyrrolidine (2.6 mL, 31.7 mmol) dropwise. Then the mixture was heated at 70° C. for 3 h. After cooled to room temperature, the mixture was filtered and the precipitate was collected, dried to give the title compound as a yellow solid (10 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07776875B2 |
|---|
| Source dataset | uspto-grants-2010_08 |
|---|
| ORD ID | ord-d7380f3f3785486ba72a8cbb0bbec6fc |
|---|
| Source note | uspto-grants-2010_08 |
|---|
