Pyrrolidine → Z-6-chloro-3-[5-chloro-2-(4-methoxy-phenoxy)-benzylidene]-1,3-dihydro-indol-2-one

Participants

Reaction Conditions

Reaction Steps

To the mixture of 6-chlorooxindole (8.3 g, 49.7 mmol) and 5-chloro-2-(4-methoxy-phenoxy)-benzaldehyde (13 g, 49.7 mmol) in methanol (100 mL) was added pyrrolidine (4.1 mL, 49.5 mmol) dropwise. The mixture was then heated at 70° C. for 3 h. After cooled to room temperature, the mixture was filtered and the precipitate was collected, dried to give the title compound as a yellow solid (15.5 g).

Provenance & Evidence