HuagongsheHuagongshe Chemistry Print Report · For research reference only
Pyrrolidine → Z-1-[4-Chloro-2-(6-chloro-2-oxo-1,2-dihydro-indol-3-ylidenemethyl)-phenoxymethyl]-cyclopropanecarbonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Pyrrolidine | HCID 31268 | — |
| Reactant | 6-Chloro-1,3-dihydroindol-2-one | HCID 736344 | — |
| Reactant | 1-(4-Chloro-2-formyl-phenoxymethyl)-cyclopentanecarbonitrile | HCID 57750121 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | Z-1-[4-Chloro-2-(6-chloro-2-oxo-1,2-dihydro-indol-3-ylidenemethyl)-phenoxymethyl]-cyclopropanecarbonitrile | HCID 86632071 | 53.4% |
Reaction Steps
In a manner similar to the method described in Example 1b, 1-(4-chloro-2-formyl-phenoxymethyl)-cyclopentanecarbonitrile (4.7 g, 20 mmol) was reacted with 6-chlorooxindole (2.78 g, 16.67 mmol) and pyrrolidine (1.54 g, 21.67 mmol) in methanol to give the title compound as a yellow solid (3.43 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07776875B2 |
| Source dataset | uspto-grants-2010_08 |
| ORD ID | ord-76d9a18b2a3349bfa5d60f0c886c1094 |
| Source note | uspto-grants-2010_08 |