Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Pyrrolidine | HCID 31268 | — |
| Reactant | 6-Chloro-1,3-dihydroindol-2-one | HCID 736344 | — |
| Reactant | HCID 4767035 | HCID 4767035 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | HCID 86632076 | HCID 86632076 | 22.4% |
Reaction Steps
To the mixture of 6-chlorooxindole (18.4 g, 0.110 mol) and (4-chloro-2-formyl-phenoxy)-acetonitrile (21.5 g, 0.110 mol) in methanol (200 mL) was added pyrrolidine (8.60 g, 0.121 mol) dropwise. Then the mixture was heated at 70° C. for 2 h. After cooled to room temperature, the mixture was filtered. The precipitate was collected and dried to give the title compound as a yellow solid (8.5 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07776875B2 |
|---|
| Source dataset | uspto-grants-2010_08 |
|---|
| ORD ID | ord-7b2d2d6ad0d14e26809963cd8f34c921 |
|---|
| Source note | uspto-grants-2010_08 |
|---|
