HuagongsheHuagongshe Chemistry Print Report · For research reference only
Pyrrolidine → Z-4-[4-chloro-2-(6-chloro-2-oxo-1,2-dihydro-indol-3-ylidenemethyl)-phenyl]-piperazine-1-carboxylic acid tert-butyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Pyrrolidine | HCID 31268 | — |
| Reactant | 6-Chloro-1,3-dihydroindol-2-one | HCID 736344 | — |
| Reactant | tert-butyl 4-(4-chloro-2-formylphenyl)tetrahydro-1(2H)-pyrazinecarboxylate | HCID 11529912 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | Z-4-[4-chloro-2-(6-chloro-2-oxo-1,2-dihydro-indol-3-ylidenemethyl)-phenyl]-piperazine-1-carboxylic acid tert-butyl ester | HCID 86632079 | 92.8% |
Reaction Steps
In a manner similar to the method described in Example 1b, 4-(4-chloro-2-formyl-phenyl)-piperazine-1-carboxylic acid tert-butyl ester (8 g, 25 mmol) was reacted with 6-chlorooxindole (4.1 g, 25 mmol) and pyrrolidine (1.8 g, 25 mmol) in methanol (50 mL) to give the title compound as a yellow solid (11 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07776875B2 |
| Source dataset | uspto-grants-2010_08 |
| ORD ID | ord-a60c2a01f5e54dbb93e3ddcb9b2a713b |
| Source note | uspto-grants-2010_08 |