1-(5-Fluoro-2-methylphenyl)-3-trimethylsilyoxy-2-aza-1,3-butadiene → HCID 74928508, compound

Participants

Reaction Steps

In a manner similar to the method described in Example 1e, E/Z-3-[2-(4-tert-butoxycarbonyl-piperazin-1-yl)-5-chloro-benzylidene]-6-chloro-2-oxo-2,3-dihydro-indole-1-carboxylic acid tert-butyl ester (3 g, 5.2 mmol) was reacted with 1-(5-fluoro-2-methyl-phenyl)-3-trimethylsilyoxy-2-aza-1,3-butadiene (14 mmol) in toluene to give the title compound as a white solid (600 mg).

Provenance & Evidence