Trifluoroacetic acid → HCID 74928536, compound

Participants

Reaction Steps

At room temperature, trifluoroacetic acid (2 mL) was added into a solution of racemic (2′S,3S,4′R)-4′-[2-(4-tert-butoxycarbonyl-piperazin-1-yl)-5-chloro-phenyl]-6-chloro-2′-(5-fluoro-2-methyl-phenyl)spiro[3H-indole-3,3′-piperidine]-2,6′(1H)-dione (280 mg, 0.43 mmol) in DCM (10 mL). After stirred for 2 h, the mixture was concentrated. The residue was dissolved in EtOAc, washed with 1 N NaOH and water, dried over anhydrous Na2SO4 and concentrated to give the title compound as a light yellow solid (230 mg).

Provenance & Evidence