HCID 86632081, compound → HCID 86632093, compound

HRID 504573Notes

Reaction equation

HRID 504573 reaction equation
C(OC([N:8]1[C:16]2[C:11](=[CH:12][CH:13]=[C:14]([Cl:17])[CH:15]=2)/[C:10](=[CH:18]/[C:19]2[CH:24]=[C:23]([Cl:25])[CH:22]=[CH:21][C:20]=2[O:26][C:27]([C:30]([O:32][CH3:33])=[O:31])([CH3:29])[CH3:28])/[C:9]1=[O:34])=O)(C)(C)C.[CH3:35][C:36]1[CH:37]=[CH:38][C:39]([O:51][CH3:52])=[C:40]([CH:42]=[N:43][C:44]([O:46][Si](C)(C)C)=[CH2:45])[CH:41]=1>C1(C)C=CC=CC=1>[Cl:17][C:14]1[CH:15]=[C:16]2[NH:8][C:9](=[O:34])[C:10]3([CH:18]([C:19]4[CH:24]=[C:23]([Cl:25])[CH:22]=[CH:21][C:20]=4[O:26][C:27]([C:30]([O:32][CH3:33])=[O:31])([CH3:29])[CH3:28])[CH2:45][C:44](=[O:46])[NH:43][CH:42]3[C:40]3[CH:41]=[C:36]([CH3:35])[CH:37]=[CH:38][C:39]=3[O:51][CH3:52])[C:11]2=[CH:12][CH:13]=1

Participants

4

Reactant 2

HCID 86632081HCID 86632081, compoundHCID 86632092HCID 86632092, compound

Product 1

HCID 86632093HCID 86632093, compoundYield 2.3%

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

In a manner similar to the method described in Example 10d, E/Z-6-chloro-3-[5-chloro-2-(1-methoxycarbonyl-1-methyl-ethoxy)-benzylidene]-2-oxo-2,3-dihydro-indole-1-carboxylic acid tert-butyl ester (5 g, 10.31 mmol) prepared in Example 1c was reacted with 1-(5-methyl-2-methoxy-phenyl)-3-trimethylsilyoxy-2-aza-1,3-butadiene (51 mmol) in toluene to give the title compound as a white solid (143 mg).

Sources & evidence

ORD record
ord-caa8a001a7c1430194030f982dddde8d
Source dataset
uspto-grants-2010_08
Patent number
US07776875B2

Reaction notes

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