HRID50459

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：Cc1ccc(S(=O)(=O)NC(=O)NCCc2ccc(-n3c(C(C)O)nc4cc(C(F)(F)F)c(Cl)cc43)cc2)cc1

HCID21876092

未命名化合物

PRODUCTS

生成物

结构：CC(=O)c1nc2cc(C(F)(F)F)c(Cl)cc2n1-c1ccc(CCNC(=O)NS(=O)(=O)c2ccc(C)cc2)cc1

HCID21876327

未命名化合物

收率 88%

AUXILIARIES

试剂、催化剂与溶剂

催化剂HCID14801

Manganese oxide (Mn2O4)

MnO2

溶剂HCID6344

Dichloromethane

CH2Cl2

PROCEDURE

实验过程

A solution of 1-[6-chloro-1-[4-(2-chloroethyl)phenyl]-5-(trifluoromethyl)-1H-benzimidazol-2-yl]ethanol (Example 367, step 1, 400 mg, 1 mmol) in CH2Cl2 was added MnO2 (2.7 g, 32 mmol) . The mixture was stirred at room temperature for 24 h. This was directly purified by flash column chromatography eluting with hexane/ethyl acetate (4:1) to afford 350 mg (88%) of the title compound as white solids.

WORKUP

后处理

customThis was directly purified by flash column chromatography
washeluting with hexane/ethyl acetate (4:1)

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-b5676d1a0703492db75a3f35f180e938
来源数据集: uspto-grants-2004_03
DOI: 10.6084/m9.figshare.5104873.v1
专利: US06710054B2
来源说明: uspto-grants-2004_03

反应 SMILES

[Cl:1][C:2]1[C:3]([C:36]([F:39])([F:38])[F:37])=[CH:4][C:5]2[N:9]=[C:8]([CH:10]([OH:12])[CH3:11])[N:7]([C:13]3[CH:18]=[CH:17][C:16]([CH2:19][CH2:20][NH:21][C:22]([NH:24][S:25]([C:28]4[CH:33]=[CH:32][C:31]([CH3:34])=[CH:30][CH:29]=4)(=[O:27])=[O:26])=[O:23])=[CH:15][CH:14]=3)[C:6]=2[CH:35]=1>C(Cl)Cl.O=[Mn]=O>[C:10]([C:8]1[N:7]([C:13]2[CH:18]=[CH:17][C:16]([CH2:19][CH2:20][NH:21][C:22]([NH:24][S:25]([C:28]3[CH:33]=[CH:32][C:31]([CH3:34])=[CH:30][CH:29]=3)(=[O:27])=[O:26])=[O:23])=[CH:15][CH:14]=2)[C:6]2[CH:35]=[C:2]([Cl:1])[C:3]([C:36]([F:38])([F:39])[F:37])=[CH:4][C:5]=2[N:9]=1)(=[O:12])[CH3:11]