反应详情

A mixture of N-{2-[5-(hydroxymethyl)-1,3-thiazol-2-yl]-1H-indol-7-yl}-N-methylthiophene-2-sulfonamide (0.10 g), thionyl chloride (0.03 ml), N,N-dimethylformamide (one drop) and tetrahydrofuran (6 ml) was stirred overnight at room temperature. Water was added to the reaction mixture, and the mixture was extracted with ethyl acetate. The ethyl acetate layer was washed successively with saturated brine, aqueous sodium bicarbonate and saturated brine, dried (MgSO4), and concentrated to give the title compound (0.08 g, yield 76%) as yellow crystals. melting point 204-205° C.

1. extractionthe mixture was extracted with ethyl acetate
2. washThe ethyl acetate layer was washed successively with saturated brine, aqueous sodium bicarbonate and saturated brine
3. dry with materialdried (MgSO4)
4. concentrationconcentrated