HuagongsheHuagongshe Chemistry Print Report · For research reference only
Morpholine → 2-Chloro-4-(morpholin-4-yl)thieno(3,2-d)pyrimidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Morpholine | HCID 8083 | — |
| Reactant | 2,4-Dichlorothieno[3,2-d]pyrimidine | HCID 12712832 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 2-Chloro-4-(morpholin-4-yl)thieno(3,2-d)pyrimidine | HCID 20284971 | 100% |
Reaction Steps
A mixture of 2,4-dichloro-thieno[3,2-d]pyrimidine (VIII), (8.68 g, 42.34 mmol), morpholine (8.11 mL, 2.2 eq.) and MeOH (150 mL) was stirred at room temperature for 1 h. The reaction mixture was then filtered, washed with water and MeOH, to yield the title compound as a white solid (11.04 g, 100%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07781433B2 |
| Source dataset | uspto-grants-2010_08 |
| ORD ID | ord-df0ca650d5b945219a70a8bf57aad444 |
| Source note | uspto-grants-2010_08 |