2-[2-(3,5-Difluoro-phenyl)-acetylamino]-pentanoic acid → HCID 16113898, compound

HRID 505049Notes

Reaction equation

HRID 505049 reaction equation
[N+:1]([C:4]1[N:5]=[CH:6][N:7]([CH:9]([C:11]2[CH:16]=[CH:15][C:14]([C:17]([F:20])([F:19])[F:18])=[CH:13][CH:12]=2)[CH3:10])[CH:8]=1)([O-])=O.[F:21][C:22]1[CH:23]=[C:24]([CH2:29][C:30]([NH:32][CH:33]([CH2:37][CH2:38][CH3:39])[C:34](O)=[O:35])=[O:31])[CH:25]=[C:26]([F:28])[CH:27]=1>>[F:18][C:17]([F:20])([F:19])[C:14]1[CH:15]=[CH:16][C:11]([CH:9]([N:7]2[CH:8]=[C:4]([NH:1][C:34](=[O:35])[C@@H:33]([NH:32][C:30](=[O:31])[CH2:29][C:24]3[CH:25]=[C:26]([F:28])[CH:27]=[C:22]([F:21])[CH:23]=3)[CH2:37][CH2:38][CH3:39])[N:5]=[CH:6]2)[CH3:10])=[CH:12][CH:13]=1

Participants

3

Reactant 2

HCID 219429862-[2-(3,5-Difluoro-phenyl)-acetylamino]-pentanoic acidHCID 684635454-Nitro-1-[1-(4-trifluoromethyl-phenyl)-ethyl]-1H-imidazole

Product 1

HCID 16113898HCID 16113898, compound

Procedure

4-Nitro-1-[1-(4-trifluoromethyl-phenyl)-ethyl]-1H-imidazole was reduced and then coupled with 2-[2-(3,5-Difluoro-phenyl)-acetylamino]-pentanoic acid (U.S. Ser. No. 11/078,898 filed Mar. 11, 2005) to afford the title compound: MS 509.5 m/z (M+1).

Sources & evidence

ORD record
ord-6d470364bfa740a79f4be560ed382acc
Source dataset
uspto-grants-2010_08
Patent number
US07781435B2

Reaction notes

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