6,8-Difluoro-2-tetralone → (S)-2-(6,8-Difluoro-1,2,3,4-tetrahydro-naphthalen-2-ylamino)-pentanoic acid (1-{1,1-dimethyl-3-[(pyridin-2-ylmethyl)-amino]-propyl}-1H-imidazol-4-yl)-amide

HRID 505053Notes

Reaction equation

HRID 505053 reaction equation
[CH3:1][C:2]([N:14]1[CH:18]=[C:17]([NH:19][C:20](=[O:26])[CH:21]([NH2:25])[CH2:22][CH2:23][CH3:24])[N:16]=[CH:15]1)([CH3:13])[CH2:3][CH2:4][NH:5][CH2:6][C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][N:8]=1.[F:27][C:28]1[CH:29]=[C:30]2[C:35](=[C:36]([F:38])[CH:37]=1)[CH2:34][C:33](=O)[CH2:32][CH2:31]2>>[CH3:1][C:2]([N:14]1[CH:18]=[C:17]([NH:19][C:20](=[O:26])[C@@H:21]([NH:25][CH:33]2[CH2:32][CH2:31][C:30]3[C:35](=[C:36]([F:38])[CH:37]=[C:28]([F:27])[CH:29]=3)[CH2:34]2)[CH2:22][CH2:23][CH3:24])[N:16]=[CH:15]1)([CH3:13])[CH2:3][CH2:4][NH:5][CH2:6][C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][N:8]=1

Participants

3

Reactant 2

HCID 40764316,8-Difluoro-2-tetraloneHCID 866114582-Amino-pentanoic acid (1-{1,1-dimethyl-3-[(pyridin-2-ylmethyl)-amino]-propyl}-1H-imidazol-4-yl)-amide

Product 1

HCID 86611457(S)-2-(6,8-Difluoro-1,2,3,4-tetrahydro-naphthalen-2-ylamino)-pentanoic acid (1-{1,1-dimethyl-3-[(pyridin-2-ylmethyl)-amino]-propyl}-1H-imidazol-4-yl)-amide

Procedure

2-Amino-pentanoic acid (1-{1,1-dimethyl-3-[(pyridin-2-ylmethyl)-amino]-propyl}-1H-imidazol-4-yl)-amide was reacted with 6,8-Difluoro-3,4-dihydro-1H-naphthalen-2-one to afford the title: 525.5 m/z (M+1).

Workup

  1. customto afford the title

Sources & evidence

ORD record
ord-59730945cb1e4f52ba0892fafb6f512f
Source dataset
uspto-grants-2010_08
Patent number
US07781435B2

Reaction notes

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