HRID505056

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CC1CN(CC(C)(C)n2cnc([N+](=O)[O-])c2)CC(C)O1

HCID67164043

未命名化合物

结构：O=C(Cc1cc(F)cc(F)c1)N[C@H](C(=O)O)c1ccccc1

HCID68464834

未命名化合物

PRODUCTS

生成物

结构：C[C@@H]1CN(CC(C)(C)n2cnc(NC(=O)[C@@H](NC(=O)Cc3cc(F)cc(F)c3)c3ccccc3)c2)C[C@H](C)O1

HCID68465524

未命名化合物

PROCEDURE

实验过程

2,6-Dimethyl-4-[2-methyl-2-(4-nitro-imidazol-1-yl)-propyl]-morpholine (U.S. Ser. No. 11/078,898 filed Mar. 11, 2005) was reduced and coupled with (S)-2-(2-(3,5-difluorophenyl)acetamido)-2-phenylacetic acid to afford the title compound: MS 540 m/z (M+1).

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-1f313381ea614a1cb43cf5c34ccc6663
来源数据集: uspto-grants-2010_08
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07781435B2
来源说明: uspto-grants-2010_08

反应 SMILES

[CH3:1][CH:2]1[O:7][CH:6]([CH3:8])[CH2:5][N:4]([CH2:9][C:10]([CH3:20])([N:12]2[CH:16]=[C:15]([N+:17]([O-])=O)[N:14]=[CH:13]2)[CH3:11])[CH2:3]1.[F:21][C:22]1[CH:23]=[C:24]([CH2:29][C:30]([NH:32][C@@H:33]([C:37]2[CH:42]=[CH:41][CH:40]=[CH:39][CH:38]=2)[C:34](O)=[O:35])=[O:31])[CH:25]=[C:26]([F:28])[CH:27]=1>>[F:21][C:22]1[CH:23]=[C:24]([CH2:29][C:30]([NH:32][C@@H:33]([C:37]2[CH:42]=[CH:41][CH:40]=[CH:39][CH:38]=2)[C:34]([NH:17][C:15]2[N:14]=[CH:13][N:12]([C:10]([CH3:20])([CH3:11])[CH2:9][N:4]3[CH2:3][C@@H:2]([CH3:1])[O:7][C@@H:6]([CH3:8])[CH2:5]3)[CH:16]=2)=[O:35])=[O:31])[CH:25]=[C:26]([F:28])[CH:27]=1