HRID505057

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CC(C)(C)CNCC(C)(C)n1cnc([N+](=O)[O-])c1

HCID67164086

未命名化合物

结构：O=C(O)[C@@H](NC1CCc2cc(F)cc(F)c2C1)c1ccccc1

HCID68464622

未命名化合物

PRODUCTS

生成物

结构：CC(C)(C)CNCC(C)(C)n1cnc(NC(=O)[C@@H](NC2CCc3cc(F)cc(F)c3C2)c2ccccc2)c1

HCID16113686

未命名化合物

PROCEDURE

实验过程

2-methyl-N-neopentyl-2-(4-nitro-1H-imidazol-1-yl)propan-1-amine (U.S. Ser. No. 11/078,898 filed Mar. 11, 2005) was reduced and coupled with (S)-2-(5,7-difluoro-1,2,3,4-tetrahydronaphthalen-3-ylamino)-2-phenylacetic acid to afford the title compound: MS 524 m/z (M+1).

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-a81460a5a433475da25d8435bd1daba2
来源数据集: uspto-grants-2010_08
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07781435B2
来源说明: uspto-grants-2010_08

反应 SMILES

[CH3:1][C:2]([N:11]1[CH:15]=[C:14]([N+:16]([O-])=O)[N:13]=[CH:12]1)([CH3:10])[CH2:3][NH:4][CH2:5][C:6]([CH3:9])([CH3:8])[CH3:7].[F:19][C:20]1[CH:29]=[C:28]([F:30])[CH:27]=[C:26]2[C:21]=1[CH2:22][CH:23]([NH:31][C@@H:32]([C:36]1[CH:41]=[CH:40][CH:39]=[CH:38][CH:37]=1)[C:33](O)=[O:34])[CH2:24][CH2:25]2>>[F:30][C:28]1[CH:27]=[C:26]2[C:21](=[C:20]([F:19])[CH:29]=1)[CH2:22][CH:23]([NH:31][C@@H:32]([C:36]1[CH:37]=[CH:38][CH:39]=[CH:40][CH:41]=1)[C:33]([NH:16][C:14]1[N:13]=[CH:12][N:11]([C:2]([CH3:10])([CH3:1])[CH2:3][NH:4][CH2:5][C:6]([CH3:9])([CH3:8])[CH3:7])[CH:15]=1)=[O:34])[CH2:24][CH2:25]2