1-(2,3-dihydro-1H-inden-1-yl)-4-nitro-1H-imidazole → (S)-2-[2-(3,5-Difluoro-phenyl)-acetylamino]-pentanoic acid (1-indan-1-yl-1H-imidazol-4-yl)-amide

HRID 505058Notes

Reaction equation

HRID 505058 reaction equation
[CH:1]1([N:10]2[CH:14]=[C:13]([N+:15]([O-])=O)[N:12]=[CH:11]2)[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH2:3][CH2:2]1.[F:18][C:19]1[CH:20]=[C:21]([CH2:26][C:27]([NH:29][C@@H:30]([CH2:34][CH2:35][CH3:36])[C:31](O)=[O:32])=[O:28])[CH:22]=[C:23]([F:25])[CH:24]=1>>[CH:1]1([N:10]2[CH:14]=[C:13]([NH:15][C:31](=[O:32])[C@@H:30]([NH:29][C:27](=[O:28])[CH2:26][C:21]3[CH:22]=[C:23]([F:25])[CH:24]=[C:19]([F:18])[CH:20]=3)[CH2:34][CH2:35][CH3:36])[N:12]=[CH:11]2)[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH2:3][CH2:2]1

Participants

3

Reactant 2

HCID 207107781-(2,3-dihydro-1H-inden-1-yl)-4-nitro-1H-imidazoleHCID 68463604(S)-2-[2-(3,5-Difluoro-phenyl)-acetylamino]-pentanoic acid

Product 1

HCID 16113899(S)-2-[2-(3,5-Difluoro-phenyl)-acetylamino]-pentanoic acid (1-indan-1-yl-1H-imidazol-4-yl)-amide

Procedure

1-(2,3-dihydro-1H-inden-1-yl)-4-nitro-1H-imidazole was reduced and coupled with (S)-2-[2-(3,5-Difluoro-phenyl)-acetylamino]-pentanoic acid (U.S. Ser. No. 11/078,898 filed Mar. 11, 2005) to afford the title compound: MS 453 m/z (M+1).

Sources & evidence

ORD record
ord-8d1b190da81f42ca9f57cf2cd0d499ab
Source dataset
uspto-grants-2010_08
Patent number
US07781435B2

Reaction notes

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