HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-(4-amino-1H-imidazol-1-yl)-2-(4-fluorophenyl)ethanol → (S)-2-[2-(3,5-Difluoro-phenyl)-acetylamino]-pentanoic acid {1-[1-(4-fluoro-phenyl)-2-hydroxy-ethyl]-1H-imidazol-4-yl}-amide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-(4-amino-1H-imidazol-1-yl)-2-(4-fluorophenyl)ethanol | HCID 68459935 | — |
| Reactant | (S)-2-[2-(3,5-Difluoro-phenyl)-acetylamino]-pentanoic acid | HCID 68463604 | — |
| Product | (S)-2-[2-(3,5-Difluoro-phenyl)-acetylamino]-pentanoic acid {1-[1-(4-fluoro-phenyl)-2-hydroxy-ethyl]-1H-imidazol-4-yl}-amide | HCID 16113900 | — |
Reaction Steps
2-(4-amino-1H-imidazol-1-yl)-2-(4-fluorophenyl)ethanol was reduced and coupled with (S)-2-[2-(3,5-Difluoro-phenyl)-acetylamino]-pentanoic acid (U.S. Ser. No. 11/078,898 filed Mar. 11, 2005) to afford the title compound: MS 475 m/z (M+1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07781435B2 |
| Source dataset | uspto-grants-2010_08 |
| ORD ID | ord-683be42594d8469584cbe5e35c8876e4 |
| Source note | uspto-grants-2010_08 |