HuagongsheHuagongshe Chemistry Print Report · For research reference only
(S)-2-[2-(3,5-Difluoro-phenyl)-acetylamino]-pentanoic acid → (S)-2-[2-(3,5-Difluoro-phenyl)-acetylamino]-pentanoic acid [1-(2-hydroxymethyl-phenyl)-1H-imidazol-4-yl]-amide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (S)-2-[2-(3,5-Difluoro-phenyl)-acetylamino]-pentanoic acid | HCID 68463604 | — |
| Reactant | (2-(4-nitro-1H-imidazol-1-yl)phenyl)methanol | HCID 68464832 | — |
| Product | (S)-2-[2-(3,5-Difluoro-phenyl)-acetylamino]-pentanoic acid [1-(2-hydroxymethyl-phenyl)-1H-imidazol-4-yl]-amide | HCID 16113791 | — |
Reaction Steps
(2-(4-nitro-1H-imidazol-1-yl)phenyl)methanol was reduced and coupled with (S)-2-[2-(3,5-Difluoro-phenyl)-acetylamino]-pentanoic acid (U.S. Ser. No. 11/078,898 filed Mar. 11, 2005) to afford the title compound: MS 443 m/z (M+1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07781435B2 |
| Source dataset | uspto-grants-2010_08 |
| ORD ID | ord-31e2c3b03bbb4e42b5bac369773e119e |
| Source note | uspto-grants-2010_08 |