HCID 21102310, compound → HCID 86611460, compound

HRID 505063Notes

Reaction equation

HRID 505063 reaction equation
[CH3:1][C:2]([CH3:22])([CH3:21])[CH2:3][NH:4][CH2:5][C@H:6]([N:13]1[CH:17]=[C:16]([N+:18]([O-])=O)[N:15]=[CH:14]1)[C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1.[F:23][C:24]1[CH:25]=[C:26]2[C:31](=[C:32]([F:34])[CH:33]=1)[CH2:30][CH:29]([NH:35][C@@H:36]([CH2:40][CH2:41][CH3:42])[C:37](O)=[O:38])[CH2:28][CH2:27]2>>[CH3:1][C:2]([CH3:22])([CH3:21])[CH2:3][NH:4][CH2:5][C@@H:6]([N:13]1[CH:17]=[C:16]([NH:18][C:37](=[O:38])[C@@H:36]([NH:35][CH:29]2[CH2:28][CH2:27][C:26]3[C:31](=[C:32]([F:34])[CH:33]=[C:24]([F:23])[CH:25]=3)[CH2:30]2)[CH2:40][CH2:41][CH3:42])[N:15]=[CH:14]1)[C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1

Participants

3

Reactant 2

HCID 21102310HCID 21102310, compoundHCID 68462871HCID 68462871, compound

Product 1

HCID 86611460HCID 86611460, compound

Procedure

(R)-2,2-dimethyl-N-(2-(4-nitro-1H-imidazol-1-yl)-2-phenylethyl)propan-1-amine was reduced and coupled with (S)-2-(6,8-Difluoro-1,2,3,4-tetrahydro-naphthalen-2-ylamino)-pentanoic acid (U.S. Ser. No. 11/078,898 filed Mar. 11, 2005) to afford the title compound: MS 538 m/z (M+1).

Sources & evidence

ORD record
ord-b5b0bc105aa5441393a61da8bcfdb344
Source dataset
uspto-grants-2010_08
Patent number
US07781435B2

Reaction notes

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