Hydrochloric Acid → [6-Chloro-3-(2,2,2-trifluoro-acetyl)-indol-1-yl]-acetic acid

Participants

Reaction Steps

To as stirred solution of 2 g (6.3 mmol) of [6-chloro-3-(2,2,2-trifluoro-acetyl)-indol-1-yl]-acetic acid methyl ester in 45 ml of THF/MeOH/H2O 1/1/1, at 40° C., were added 0.79 g (18.9 mmol, 3 eq.) of LiOH.H2O. After 1 hour, the reaction mixture was diluted in EtOAc, acidified with aq.HCl 1M. The organic phase were dried over Na2SO4, and concentrated under vacuo to afford 1.9 g (99%) of [6-chloro-3-(2,2,2-trifluoro-acetyl)-indol-1-yl]-acetic acid as a white solid.

Provenance & Evidence