HuagongsheHuagongshe Chemistry Print Report · For research reference only
(6-chloro-1H-indol-3-yl)-[4-(2,6-dimethoxy-phenyl)-piperidin-1-yl]-methanone → (6-Chloro-1-pyridin-2-ylmethyl-1H-indol-3-yl)-[4-(2,6-dimethoxy-phenyl)-piperidin-1-yl]-methanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (6-chloro-1H-indol-3-yl)-[4-(2,6-dimethoxy-phenyl)-piperidin-1-yl]-methanone | HCID 16062188 | — |
| Reactant | Methanesulfonic acid pyridin-2-ylmethyl ester | HCID 22417657 | — |
| Product | (6-Chloro-1-pyridin-2-ylmethyl-1H-indol-3-yl)-[4-(2,6-dimethoxy-phenyl)-piperidin-1-yl]-methanone | HCID 16062307 | — |
Reaction Steps
Following general procedure II, the alkylation of (6-chloro-1H-indol-3-yl)-[4-(2,6-dimethoxy-phenyl)-piperidin-1-yl]-methanone (preparation described herein), with methanesulfonic acid pyridin-2-ylmethyl ester (described in WO 9955318) gave the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07781436B2 |
| Source dataset | uspto-grants-2010_08 |
| ORD ID | ord-b6b37a7c6c20495c936e9827a0d68fd7 |
| Source note | uspto-grants-2010_08 |