HuagongsheHuagongshe Chemistry Print Report · For research reference only
3,5-Difluorobenzyl chloride → [6-Chloro-1-(3,5-difluoro-benzyl)-1H-indol-3-yl]-[4-(2,6-dimethoxy-phenyl)-piperidin-1-yl]-methanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3,5-Difluorobenzyl chloride | HCID 2736955 | — |
| Reactant | (6-chloro-1H-indol-3-yl)-[4-(2,6-dimethoxy-phenyl)-piperidin-1-yl]-methanone | HCID 16062188 | — |
| Product | [6-Chloro-1-(3,5-difluoro-benzyl)-1H-indol-3-yl]-[4-(2,6-dimethoxy-phenyl)-piperidin-1-yl]-methanone | HCID 16062311 | — |
Reaction Steps
Following general procedure II, the alkylation of (6-chloro-1H-indol-3-yl)-[4-(2,6-dimethoxy-phenyl)-piperidin-1-yl]-methanone (preparation described herein), with (commercially available) 1-chloromethyl-3,5-difluoro-benzene gave the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07781436B2 |
| Source dataset | uspto-grants-2010_08 |
| ORD ID | ord-1f70680499d64cf8801175e5c40b754d |
| Source note | uspto-grants-2010_08 |