3,5-Difluorobenzyl chloride → [6-Chloro-1-(3,5-difluoro-benzyl)-1H-indol-3-yl]-[4-(2-methoxy-phenyl)-piperidin-1-yl]-methanone

HRID 505097Notes

Reaction equation

HRID 505097 reaction equation
[Cl:1][C:2]1[CH:10]=[C:9]2[C:5]([C:6]([C:11]([N:13]3[CH2:18][CH2:17][CH:16]([C:19]4[CH:24]=[CH:23][CH:22]=[CH:21][C:20]=4[O:25][CH3:26])[CH2:15][CH2:14]3)=[O:12])=[CH:7][NH:8]2)=[CH:4][CH:3]=1.Cl[CH2:28][C:29]1[CH:34]=[C:33]([F:35])[CH:32]=[C:31]([F:36])[CH:30]=1>>[Cl:1][C:2]1[CH:10]=[C:9]2[C:5]([C:6]([C:11]([N:13]3[CH2:18][CH2:17][CH:16]([C:19]4[CH:24]=[CH:23][CH:22]=[CH:21][C:20]=4[O:25][CH3:26])[CH2:15][CH2:14]3)=[O:12])=[CH:7][N:8]2[CH2:28][C:29]2[CH:34]=[C:33]([F:35])[CH:32]=[C:31]([F:36])[CH:30]=2)=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 27369553,5-Difluorobenzyl chlorideHCID 59429632(6-Chloro-1H-indol-3-yl)[4-(2-methoxyphenyl)piperidin-1-yl]methanone

Product 1

HCID 16062435[6-Chloro-1-(3,5-difluoro-benzyl)-1H-indol-3-yl]-[4-(2-methoxy-phenyl)-piperidin-1-yl]-methanone

Procedure

Following general procedure II, the alkylation of (6-chloro-1H-indol-3-yl)-[4-(2-methoxy-phenyl)-piperidin-1-yl]-methanone (preparation described herein), with (commercially available) 1-chloromethyl-3,5-difluoro-benzene gave the title compound.

Sources & evidence

ORD record
ord-71c5b678ccad47fcb53b9badce8d9196
Source dataset
uspto-grants-2010_08
Patent number
US07781436B2

Reaction notes

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