2-chloro-N,N-dimethylacetamide → HCID 59429654, compound

HRID 505101Notes

Reaction equation

HRID 505101 reaction equation
Cl[C:2]1[CH:10]=[C:9]2[C:5]([C:6]([C:11]([N:13]3[CH2:18][CH2:17][CH:16]([C:19]4[C:24]([O:25][CH3:26])=[CH:23][CH:22]=[CH:21][C:20]=4[O:27][CH3:28])[CH2:15][CH2:14]3)=[O:12])=[CH:7][NH:8]2)=[CH:4][CH:3]=1.Cl[CH2:30][C:31]([N:33]([CH3:35])[CH3:34])=[O:32]>>[CH3:28][O:27][C:20]1[CH:21]=[CH:22][CH:23]=[C:24]([O:25][CH3:26])[C:19]=1[CH:16]1[CH2:17][CH2:18][N:13]([C:11]([C:6]2[C:5]3[C:9](=[CH:10][CH:2]=[CH:3][CH:4]=3)[N:8]([CH2:30][C:31]([N:33]([CH3:35])[CH3:34])=[O:32])[CH:7]=2)=[O:12])[CH2:14][CH2:15]1

Participants

3

Reactant 2

HCID 758862-chloro-N,N-dimethylacetamideHCID 16062188(6-chloro-1H-indol-3-yl)-[4-(2,6-dimethoxy-phenyl)-piperidin-1-yl]-methanone

Product 1

HCID 59429654HCID 59429654, compound

Procedure

Following general procedure II, the alkylation of (6-chloro-1H-indol-3-yl)-[4-(2,6-dimethoxy-phenyl)-piperidin-1-yl]-methanone (preparation described herein), with (commercially available) 2-chloro-N,N-dimethyl-acetamide gave the title compound.

Sources & evidence

ORD record
ord-518b6742e24048a983c763dc2c064691
Source dataset
uspto-grants-2010_08
Patent number
US07781436B2

Reaction notes

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