HuagongsheHuagongshe Chemistry Print Report · For research reference only
(2-Methylpyridin-4-yl)methanol → [6-Chloro-1-(2-methyl-pyridin-4-ylmethyl)-1H-indol-3-yl]-[4-(2,6-dimethoxy-phenyl)-piperidin-1-yl]-methanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (2-Methylpyridin-4-yl)methanol | HCID 9942144 | — |
| Reactant | (6-chloro-1H-indol-3-yl)-[4-(2,6-dimethoxy-phenyl)-piperidin-1-yl]-methanone | HCID 16062188 | — |
| Reactant | Methanesulfonic acid 2-methyl-pyridin-4-ylmethyl ester | HCID 59184833 | — |
| Product | [6-Chloro-1-(2-methyl-pyridin-4-ylmethyl)-1H-indol-3-yl]-[4-(2,6-dimethoxy-phenyl)-piperidin-1-yl]-methanone | HCID 16062573 | — |
Reaction Steps
Following general procedure II, the alkylation of (6-chloro-1H-indol-3-yl)-[4-(2,6-dimethoxy-phenyl)-piperidin-1-yl]-methanone (preparation described herein), with methanesulfonic acid 2-methyl-pyridin-4-ylmethyl ester (prepared by mesylation of the commercially available (2-methyl-pyridin-4-yl)-methanol) gave the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07781436B2 |
| Source dataset | uspto-grants-2010_08 |
| ORD ID | ord-6a281e0f6cf4474aa75c2ec0c6b1c536 |
| Source note | uspto-grants-2010_08 |