2-Chloro-1-(4-methylpiperazin-1-yl)ethanone → HCID 59429618, compound

HRID 505103Notes

Reaction equation

HRID 505103 reaction equation
Cl[C:2]1[CH:10]=[C:9]2[C:5]([C:6]([C:11]([N:13]3[CH2:18][CH2:17][CH:16]([C:19]4[C:24]([O:25][CH3:26])=[CH:23][CH:22]=[CH:21][C:20]=4[O:27][CH3:28])[CH2:15][CH2:14]3)=[O:12])=[CH:7][NH:8]2)=[CH:4][CH:3]=1.Cl[CH2:30][C:31]([N:33]1[CH2:38][CH2:37][N:36]([CH3:39])[CH2:35][CH2:34]1)=[O:32]>>[CH3:26][O:25][C:24]1[CH:23]=[CH:22][CH:21]=[C:20]([O:27][CH3:28])[C:19]=1[CH:16]1[CH2:17][CH2:18][N:13]([C:11]([C:6]2[C:5]3[C:9](=[CH:10][CH:2]=[CH:3][CH:4]=3)[N:8]([CH2:30][C:31]([N:33]3[CH2:38][CH2:37][N:36]([CH3:39])[CH2:35][CH2:34]3)=[O:32])[CH:7]=2)=[O:12])[CH2:14][CH2:15]1

Participants

3

Reactant 2

HCID 8181732-Chloro-1-(4-methylpiperazin-1-yl)ethanoneHCID 16062188(6-chloro-1H-indol-3-yl)-[4-(2,6-dimethoxy-phenyl)-piperidin-1-yl]-methanone

Product 1

HCID 59429618HCID 59429618, compound

Procedure

Following general procedure II, the alkylation of (6-chloro-1H-indol-3-yl)-[4-(2,6-dimethoxy-phenyl)-piperidin-1-yl]-methanone (preparation described herein), with (commercially available) 2-chloro-1-(4-methyl-piperazin-1-yl)-ethanone gave the title compound.

Sources & evidence

ORD record
ord-c70397eff9fc44c4b02cff81234c1e24
Source dataset
uspto-grants-2010_08
Patent number
US07781436B2

Reaction notes

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