2-chloro-N,N-dimethylacetamide → 2-{6-Chloro-3-[4-(2-trifluoromethyl-phenyl)-piperidine-1-carbonyl]-indol-1-yl}-N,N-dimethyl-acetamide

Participants

Role	Name	HCID	Charge
Reactant	2-chloro-N,N-dimethylacetamide	HCID 75886	—
Reactant	(6-Chloro-1H-indol-3-yl)-[4-(2-trifluoromethyl-phenyl)-piperidin-1-yl]-methanone	HCID 59429661	—
Product	2-{6-Chloro-3-[4-(2-trifluoromethyl-phenyl)-piperidine-1-carbonyl]-indol-1-yl}-N,N-dimethyl-acetamide	HCID 16062959	—

Reaction Steps

Analogous to general procedure I, the coupling of (6-chloro-1H-indol-3-yl)-[4-(2-trifluoromethyl-phenyl)-piperidin-1-yl]-methanone (prepared herein) with (commercially available) 2-chloro-N,N-dimethyl-acetamide gave the title compound.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07781436B2
Source dataset	uspto-grants-2010_08
ORD ID	ord-09b1a29563d149f39dc028652e4a2bac
Source note	uspto-grants-2010_08