2-Chloro-1-(4-methylpiperazin-1-yl)ethanone → 2-{6-Chloro-3-[4-(2-ethoxy-phenyl)-piperazine-1-carbonyl]-indol-1-yl}-1-(4-methyl-piperazin-1-yl)-ethanone

Participants

Role	Name	HCID	Charge
Reactant	2-Chloro-1-(4-methylpiperazin-1-yl)ethanone	HCID 818173	—
Reactant	(6-Chloro-1H-indol-3-yl)[4-(2-ethoxyphenyl)piperazin-1-yl]methanone	HCID 16061511	—
Product	2-{6-Chloro-3-[4-(2-ethoxy-phenyl)-piperazine-1-carbonyl]-indol-1-yl}-1-(4-methyl-piperazin-1-yl)-ethanone	HCID 16061512	—

Reaction Steps

Following general procedure II, the alkylation of (6-chloro-1H-indol-3-yl)-[4-(2-ethoxy-phenyl)-piperazin-1-yl]-methanone (preparation described herein), with (commercially available) 2-chloro-1-(4-methyl-piperazin-1-yl)-ethanone gave the title compound.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07781436B2
Source dataset	uspto-grants-2010_08
ORD ID	ord-615c2037147e47ff8cc14476b7655394
Source note	uspto-grants-2010_08