2-Chloroethylamine → HCID 16061619, compound

HRID 505169Notes

Reaction equation

HRID 505169 reaction equation
[Cl:1][C:2]1[CH:10]=[C:9]2[C:5]([C:6]([C:11]([N:13]3[CH2:18][CH2:17][N:16]([C:19]4[CH:24]=[CH:23][CH:22]=[CH:21][C:20]=4[O:25][CH3:26])[CH2:15][CH2:14]3)=[O:12])=[CH:7][NH:8]2)=[CH:4][CH:3]=1.Cl[CH2:28][CH2:29][NH2:30]>>[NH2:30][CH2:29][CH2:28][N:8]1[C:9]2[C:5](=[CH:4][CH:3]=[C:2]([Cl:1])[CH:10]=2)[C:6]([C:11]([N:13]2[CH2:18][CH2:17][N:16]([C:19]3[CH:24]=[CH:23][CH:22]=[CH:21][C:20]=3[O:25][CH3:26])[CH2:15][CH2:14]2)=[O:12])=[CH:7]1

Participants

3

Reactant 2

HCID 133692-ChloroethylamineHCID 16063356(6-Chloro-1H-indol-3-yl)[4-(2-methoxyphenyl)piperazin-1-yl]methanone

Product 1

HCID 16061619HCID 16061619, compound

Procedure

Analogous to general procedure II, the alkylation of (6-chloro-1H-indol-3-yl)-[4-(2-methoxy-phenyl)-piperazin-1-yl]-methanone (prepared herein) with (commercially available) 2-chloro-ethylamine gave the title compound.

Sources & evidence

ORD record
ord-cde8531242ba4043b252c537b9b73ce1
Source dataset
uspto-grants-2010_08
Patent number
US07781436B2

Reaction notes

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