反应详情

温度

70 °C

A solution of (6-chloro-3-dimethylaminomethyl-isoquinolin-5-yl)-acetic acid methyl ester (515 mg, 1.76 mmol) in a mixture of methanol (10 mL) and liquid ammonia (10 mL) was stirred for 16 h in an autoclave at 70° C. After careful evaporation of the ammonia, the remaining solvent was evaporated in vacuo to afford the title compound as a brown solid (410 mg, 1.48 mmol, 84%). MS (ES+): 278 (M(C14H1635ClN3O)+H)+.

1. customAfter careful evaporation of the ammonia
2. customthe remaining solvent was evaporated in vacuo