反应详情

Sodium borohydride (62.3 mg, 1.65 mmol) was added to a stirred solution of ethyl (trans-4-{[ethyl(2-formylpyridin-3-yl)amino]methyl}cyclohexyl)acetate (136.9 mg, 0.412 mmol) in EtOH (10 mL) at room temperature. The reaction was stirred at room temperature for 1 h, then diluted with water and most of the EtOH was removed in vacuo. The resulting aqueous slurry was extracted with EtOAc (3×20 mL) and the combined extracts were washed with brine (5 mL), dried (Na2SO4) and concentrated in vacuo to afford ethyl [trans-4-({ethyl[2-(hydroxymethyl)pyridin-3-yl]amino}methyl)cyclohexyl]acetate. LCMS calc.=335.2; found=335.3 (M+1)+.

1. customwas removed in vacuo
2. extractionThe resulting aqueous slurry was extracted with EtOAc (3×20 mL)
3. washthe combined extracts were washed with brine (5 mL)
4. dry with materialdried (Na2SO4)
5. concentrationconcentrated in vacuo