反应详情

3-Chloroperbenzoic acid (77%, 120 mg, 0.486 mmol) was added to a solution of ethyl (trans-4-{[[2-({(4S,5R)-5-[3,5-bis(trifluoromethyl)phenyl]-4-methyl-2-oxo-1,3-oxazolidin-3-yl}methyl)pyridin-3-yl](ethyl)amino]methyl}cyclohexyl)acetate (152.9 mg, 0.243 mmol) in dry CH2Cl2 (10 mL) at 0° C. under N2. After 15 min at 0° C., the reaction was stirred at room temperature for 5 h. The reaction mixture was diluted with CH2Cl2 (20 mL) and washed with saturated Na2SO3 (10 mL) and saturated K2CO3 (2×20 mL). The organic layers were dried (Na2SO4) and concentrated in vacuo to afford ethyl (trans-4-{[[2-({(4S,5R)-5-[3,5-bis(trifluoromethyl)phenyl]-4-methyl-2-oxo-1,3-oxazolidin-3-yl}methyl)-1-oxidopyridin-3-yl](ethyl)amino]methyl}cyclohexyl)acetate. LCMS calc.=646.3; found=646.3 (M+1)+.

1. washwashed with saturated Na2SO3 (10 mL) and saturated K2CO3 (2×20 mL)
2. dry with materialThe organic layers were dried (Na2SO4)
3. concentrationconcentrated in vacuo