Methyl iodide → HCID 178503336, compound

HRID 505321Notes

Reaction equation

HRID 505321 reaction equation
[CH3:1][I:2].[NH:3]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[CH2:6][NH:5][C:4]1=[S:13]>C(O)C>[IH:2].[CH3:1][S:13][C:4]1[NH:5][CH2:6][C:7]2[C:12](=[CH:11][CH:10]=[CH:9][CH:8]=2)[N:3]=1

Participants

4

Reactant 2

HCID 6328Methyl iodideHCID 36448543,4-dihydro-1H-quinazoline-2-thione

Product 1

HCID 178503336HCID 178503336, compoundYield 68.2%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Methyl iodide (11.5 ml, 184 mmol) was added to a solution of 3,4-dihydro-1H-quinazoline-2-thione (7.55 g, 46 mmol) in ethanol (150 ml), and the mixture was heated to reflux (3.5 h). The majority of the solvent was then evaporated under reduced pressure, and the precipitate was collected by filtration and washed with a small amount of cold ethanol. The thus obtained title compound (9.60 g, 68%) was used in the next step without further purification.

Workup

  1. temperaturethe mixture was heated
  2. temperatureto reflux (3.5 h)
  3. customThe majority of the solvent was then evaporated under reduced pressure
  4. filtrationthe precipitate was collected by filtration
  5. washwashed with a small amount of cold ethanol

Sources & evidence

ORD record
ord-28c044463eae4443abda887d865e23ed
Source dataset
uspto-grants-2010_08
Patent number
US07781441B2

Reaction notes

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