反应详情

Methyl iodide (11.5 ml, 184 mmol) was added to a solution of 3,4-dihydro-1H-quinazoline-2-thione (7.55 g, 46 mmol) in ethanol (150 ml), and the mixture was heated to reflux (3.5 h). The majority of the solvent was then evaporated under reduced pressure, and the precipitate was collected by filtration and washed with a small amount of cold ethanol. The thus obtained title compound (9.60 g, 68%) was used in the next step without further purification.

1. temperaturethe mixture was heated
2. temperatureto reflux (3.5 h)
3. customThe majority of the solvent was then evaporated under reduced pressure
4. filtrationthe precipitate was collected by filtration
5. washwashed with a small amount of cold ethanol