2-Phenoxyethanamine → HCID 178506550, compound

HRID 505324Notes

Reaction equation

HRID 505324 reaction equation
[O:1]([CH2:8][CH2:9][NH2:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[IH:11].CS[C:14]1[NH:23][CH2:22][C:21]2[C:16](=[CH:17][CH:18]=[CH:19][CH:20]=2)[N:15]=1>C(#N)C>[IH:11].[N:15]1[C:16]2[C:21](=[CH:20][CH:19]=[CH:18][CH:17]=2)[CH2:22][NH:23][C:14]=1[NH:10][CH2:9][CH2:8][O:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 156512-PhenoxyethanamineHCID 178503336HCID 178503336, compound

Product 1

HCID 178506550HCID 178506550, compoundYield 95%

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Conditions

Temperature
80 °C

Procedure

2-Phenoxyethylamine (21 mg, 0.16 mmol) was added to a solution of 2-methylsulfanyl-3,4-dihydro-quinazoline hydroiodide (50 mg, 0.16 mmol, prepared as under example 1 [c]) in acetonitrile (1 ml), and the mixture was heated overnight (80° C.) in a screw-capped vial. The solvent was then evaporated and the mixture was suspended in diethyl ether. The title compound (41 mg, 95%) was obtained from this mixture by filtration.

Workup

  1. customThe solvent was then evaporated

Sources & evidence

ORD record
ord-1dc6b91d66dc4eeea91402e84c26f5ea
Source dataset
uspto-grants-2010_08
Patent number
US07781441B2

Reaction notes

Loading…