HCID 12052720, compound → HCID 136353684, compound

HRID 505341Notes

Reaction equation

HRID 505341 reaction equation
[N:1]1[CH:6]=[CH:5][C:4]([C:7](=O)[CH:8]([CH3:14])[C:9]([O:11]CC)=O)=[N:3][CH:2]=1.Cl.Cl.[NH:18]1[CH2:23][CH2:22][CH2:21][N:20]=[C:19]1[NH2:24]>>[CH3:14][C:8]1[C:9](=[O:11])[N:18]2[CH2:23][CH2:22][CH2:21][NH:20][C:19]2=[N:24][C:7]=1[C:4]1[CH:5]=[CH:6][N:1]=[CH:2][N:3]=1

Participants

3

Reactant 2

HCID 12052720HCID 12052720, compoundHCID 17851068HCID 17851068, compound

Product 1

HCID 136353684HCID 136353684, compound

Procedure

A mixture of 10.72 g (51.48 mmol) of ethyl 3-(4-pyrimidinyl)-2-methyl-3-oxopropionate, (prepared by analogy to the method described in patent DE 2705641 and U.S. Pat. No. 4,110,450) 6.98 g (51.48 mmol) of 1,4,5,6-tetrahydro-2-pyrimidinamine dihydrochloride

Workup

  1. custom(prepared by analogy to the method

Sources & evidence

ORD record
ord-784c075c021642a3893708c6db0198a4
Source dataset
uspto-grants-2010_08
Patent number
US07781440B2

Reaction notes

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