HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 505343Generated: October 30, 2026
Guanidine Hydrochloride → 5,5-Difluoro-1,4,5,6-tetrahydro-2-pyrimidinamine
https://huagongshe.com/reaction/505343
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Guanidine Hydrochloride | HCID 5742 | — |
| Reactant | Sodium Methoxide | HCID 10942334 | — |
| Reactant | 2,2-Difluoropropane-1,3-diamine dihydrochloride | HCID 22287769 | — |
| Product | 5,5-Difluoro-1,4,5,6-tetrahydro-2-pyrimidinamine | HCID 12052723 | — |
Reaction Steps
A mixture of 2.95 g (16.12 mmol) of 2,2-difluoro-1,3-propandiamine dihydrochloride (Tetrahedron (1994) 50(29), 8617-8632), 1.54 g (16.12 mmol) of guanidine hydrochloride and 2.19 g (32.23 mmol) of sodium methylate was heated at 150° C. during 18 h. The cooled mixture was used as such in the subsequent step.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07781440B2 |
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| Source dataset | uspto-grants-2010_08 |
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| ORD ID | ord-5c37a38c1b4c42caac3d84f1535e18be |
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| Source note | uspto-grants-2010_08 |
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