HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Carbonate → 2,2-Dimethyl-7-pyrimidin-4-yl-2,3-dihydro-1H-imidazo[1,2-a]pyrimidin-5-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | Ethyl 3-oxo-3-(pyrimidin-4-yl)propanoate | HCID 11961458 | — |
| Reactant | 5,5-dimethyl-4,5-dihydro-1H-imidazol-2-amine hydrobromide | HCID 17851060 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 2,2-Dimethyl-7-pyrimidin-4-yl-2,3-dihydro-1H-imidazo[1,2-a]pyrimidin-5-one | HCID 135811699 | — |
Reaction Steps
A mixture containing 2.0 g (10.3 mmol) of ethyl 3-(4-pyrimidinyl)-3-oxopropionate, 2.0 g (10.3 mmol) of 5,5-dimethyl-4,5-dihydro-1H-imidazol-2-ylamine hydrobromide and 2.85 g (20.6 mmol) of potassium carbonate in 15 ml of methanol were heated at reflux temperature during 18 h.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07781440B2 |
| Source dataset | uspto-grants-2010_08 |
| ORD ID | ord-764da7a90e28429eaa0b7e5260dbf668 |
| Source note | uspto-grants-2010_08 |