Ethyl 3-oxo-3-(pyrimidin-4-yl)propanoate → HCID 135738617, compound

HRID 505350Notes

Reaction equation

HRID 505350 reaction equation
[N:1]1[CH:6]=[CH:5][C:4]([C:7](=O)[CH2:8][C:9]([O:11]CC)=O)=[N:3][CH:2]=1.Br.[CH3:16][C:17]1([CH3:24])[NH:22][C:21]([NH2:23])=[N:20][CH2:19][CH2:18]1>>[CH3:16][C:17]1([CH3:24])[CH2:18][CH2:19][N:20]2[C:9](=[O:11])[CH:8]=[C:7]([C:4]3[CH:5]=[CH:6][N:1]=[CH:2][N:3]=3)[N:23]=[C:21]2[NH:22]1

Participants

3

Reactant 2

HCID 11961458Ethyl 3-oxo-3-(pyrimidin-4-yl)propanoateHCID 17858153HCID 17858153, compound

Product 1

HCID 135738617HCID 135738617, compound

Procedure

A mixture of 2.39 g (12.31 mmol) of ethyl 3-(4-pyrimidinyl)-3-oxopropionate, (prepared by analogy to the method described in patent DE 2705582), 2.33 g (11.19 mmol) 6,6-dimethyl-1,4,5,6-tetrahydro-pyrimidin-2-ylamine hydrobromide

Workup

  1. custom(prepared by analogy to the method

Sources & evidence

ORD record
ord-f59e6db8d1694e36b72da3ec1a47bbf5
Source dataset
uspto-grants-2010_08
Patent number
US07781440B2

Reaction notes

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