Sodium borohydride → HCID 11196128, compound

Participants

Reaction Conditions

Reaction Steps

Amine 11d (10.64 g, 0.042 mol) was dissolved in ethanol (100 mL) and NaBH4 (2.6 g) was added and the reaction mixture was stirred at 80-90° C. After 3 h the TLC indicated the absence of the starting material. The organic layer was washed with water (2×200 mL), brine (200 mL), dried (Na2SO4) and concentrated to provide a colorless oil (10.71 g, 100%). 1H NMR (300 MHz CDCl3) 6.79-6.67 (m, 3H), 4.43 (t, J=5.7 Hz, 1H), 3.72 (s, 3H), 3.71 (s, 3H), 3.68 (d, J=2.7 Hz, 2H), 3.28 (s, 6H), 2.7 (s, 2H).

Provenance & Evidence