Hydrochloric Acid → HCID 68461355, compound

Participants

Reaction Steps

Amine 12d (2.82 g, 11.1 mmol) and veratraldehyde (10a, 4.00 g, 0.030 mol) were reacted in concentrated hydrochloric acid as described previously for compound 9aa. The product was isolated as a yellow-orange hygroscopic solid (1.01 g, 24%), mp 242-244° C. 1H NMR (300 MHz, TFA) δ 9.52 (s, 1H), 7.75 (s, 1H), 7.43 (d, J=7.8 Hz, 1H), 7.38 (s, 1H), 7.08 (d, J=8.7 Hz, 1H), 4.56 (s, 2H), 4.10 (s, 3H), 4.09 (s, 3H), 4.04 (s, 6H). Anal. (C20H20NO4Cl.1.7H2O)C, H, N, Anal. Calcd for C20H20NO4Cl(H2O)1.7: C, 59.39; H, 5.83; N, 3.46. Found: C, 59.22; H, 5.53; N, 3.72.

Provenance & Evidence