Ammonia → 2-Methoxy-3-methyl-5-nitropyridine

HRID 505378Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 505378
S(=O)(=O)(O)O.[N+:6]([O-:9])(O)=[O:7].[CH3:10][O:11][C:12]1[C:17]([CH3:18])=[CH:16][CH:15]=[CH:14][N:13]=1.N>>[CH3:10][O:11][C:12]1[C:17]([CH3:18])=[CH:16][C:15]([N+:6]([O-:9])=[O:7])=[CH:14][N:13]=1

Komponenten

5

Edukt 4

HCID 222AmmoniaHCID 944Nitric AcidHCID 1118Sulfuric AcidHCID 130898102-Methoxy-3-methylpyridine

Produkt 1

HCID 407869042-Methoxy-3-methyl-5-nitropyridineAusbeute 74 %

Reaktionsbedingungen

Temperatur
0 °C

Versuchsvorschrift

Concentrated sulfuric acid (5 ml) and fuming nitric acid (5 ml) were added to 2-methoxy-3-methylpyridine (1.61 g, 13.1 mmol) under ice cooling, and stirred at 0° C. for 1 hour and further stirred at room temperature overnight. The reaction mixture was poured onto ice, neutralized with ammonia solution, extracted with ethyl acetate, dried over magnesium sulfate, the solvent was evaporated, thereby yielding the title compound (1.63 g, 9.71 mmol, and 74%).

Aufarbeitung

  1. stirringfurther stirred at room temperature overnight
  2. additionThe reaction mixture was poured onto ice
  3. extractionextracted with ethyl acetate
  4. dry with materialdried over magnesium sulfate
  5. customthe solvent was evaporated

Quellen und Nachweise

ORD-Eintrag
ord-4d2c7e91f8194f6c9a41a65855737413
Quelldatensatz
uspto-grants-2010_08
Patentnummer
US07781452B2

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