反应详情

温度

0 °C

Concentrated sulfuric acid (5 ml) and fuming nitric acid (5 ml) were added to 2-methoxy-3-methylpyridine (1.61 g, 13.1 mmol) under ice cooling, and stirred at 0° C. for 1 hour and further stirred at room temperature overnight. The reaction mixture was poured onto ice, neutralized with ammonia solution, extracted with ethyl acetate, dried over magnesium sulfate, the solvent was evaporated, thereby yielding the title compound (1.63 g, 9.71 mmol, and 74%).

1. stirringfurther stirred at room temperature overnight
2. additionThe reaction mixture was poured onto ice
3. extractionextracted with ethyl acetate
4. dry with materialdried over magnesium sulfate
5. customthe solvent was evaporated