2-Methoxy-3-methyl-5-nitropyridine → 6-Methoxy-5-methylpyridin-3-amine

HRID 505379Notes

Reaction equation

HRID 505379 reaction equation
[CH3:1][O:2][C:3]1[C:8]([CH3:9])=[CH:7][C:6]([N+:10]([O-])=O)=[CH:5][N:4]=1>CO>[CH3:1][O:2][C:3]1[N:4]=[CH:5][C:6]([NH2:10])=[CH:7][C:8]=1[CH3:9]

Participants

3

Reactant 1

HCID 407869042-Methoxy-3-methyl-5-nitropyridine

Product 1

HCID 407869036-Methoxy-5-methylpyridin-3-amineYield 93%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

2-Methoxy-3-methyl-5-nitropyridine (1.63 g, 9.71 mmol) was dissolved in methanol (50 ml), 10% Pd-on-carbon powder (50% water content article) (800 mg) was added, and stirred under hydrogen atmosphere for 2 hours and 10 minutes. After the reaction was completed, celite filtration was carried out, the solvent was evaporated, thereby yielding the title compound (1.25 g, 0.90 mmol, 93%) as a blue oily substance.

Workup

  1. filtrationcelite filtration
  2. customthe solvent was evaporated

Sources & evidence

ORD record
ord-f2060dff5f9e46628d01dd91f5a52398
Source dataset
uspto-grants-2010_08
Patent number
US07781452B2

Reaction notes

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