Hydrochloric Acid → HCID 178423868, compound

Participants

Reaction Conditions

Reaction Steps

41 mg of 2-[2-(2-amino-4-methylpyridin-6-yl)ethyl]-6-p-tolyl-3H-imidazo[4,5-b]pyridine (compound 7) are dissolved in 8.4 ml of dichloromethane. After cooling the solution to 0° C., 61 μl of hydrochloride in diethyl ether (strength 2.0 M) is added under stirring. Subsequently, the solvents are evaporated in vacuo. The remaining residue is redissolved in petrol ether/dichloromethane (3:1) and concentrated to dryness to afford 40 mg of the title compound as an amorphous powder of m.p. 186° C. MS: 344.4 (MH+). TLC: Rf=0.37 (dichloromethane/methanol 8:1).

Provenance & Evidence