HuagongsheHuagongshe Chemistry Print Report · For research reference only
N-[2-Amino-5-(4-chloro-phenyl)-pyridin-3-yl]-3-(6-amino-4-methyl-pyridin-2-yl)-propionamide → HCID 178428707, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N-[2-Amino-5-(4-chloro-phenyl)-pyridin-3-yl]-3-(6-amino-4-methyl-pyridin-2-yl)-propionamide | HCID 68466161 | — |
| Solvent | Dichloromethane methanol | HCID 21226129 | — |
| Product | HCID 178428707 | HCID 178428707 | 17.5% |
Reaction Steps
36 mg of N-[2-amino-5-(4-chloro-phenyl)-pyridin-3-yl]-3-(6-amino-4-methyl-pyridin-2-yl)-propionamide (compound A9) are treated with 2 g polyphosphoric acid at 125° C. for 24 h. Subsequent workup according to the procedure described herein for example A6 yields 6 mg of the title compound as a viscous oil after chromatography (dichloromethane/methanol 8:1). ESI-MS: 364.4/366.4 (MH+, 100%/36%). TLC: Rf=0.30 (dichloromethane/methanol 8:1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07781453B2 |
| Source dataset | uspto-grants-2010_08 |
| ORD ID | ord-da5b0529593a43df8ecc6e539bb4ba57 |
| Source note | uspto-grants-2010_08 |